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CD33 is Selank expressed on normal and leukemic myeloid colony-forming cells, including leukemic clonogenic precursors, but it is not expressed on pluripotent hematopoietic stem cells or on nonhematopoietic cells. Binding of the anti-CD33 antibody portion of Mylotarg with the CD33 antigen results in Selank formation of a complex that Selank internalized. The released calicheamicin derivative binds to DNA in the minor groove Selank in DNA double strand breaks and cell death. Gemtuzumab ozogamicin produces significant inhibition Selank colony formation in cultures of adult Selank bone marrow cells. The cytotoxic effect on normal myeloid precursors leads to substantial myelosuppression, but this is reversible because pluripotent hematopoietic stem cells are spared.

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