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Although prolonged estrus cycles have been noted at two to 20nbsp;times the human dose, no effects Metadate (Methylphenidate) fertility have been observed in rats treated with Neumega at doses up to 1000nbsp;mcgkgday. Neumega should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Findings in pregnant rabbits consisted of decreased fecalurine eliminations (the only toxicity noted at 1nbsp;mcgkgday in dams) as well as decreased food consumption, body weight loss, abortion, increased embryonic and fetal deaths, and decreased numbers of live fetuses. No teratogenic effects of Neumega were Metadate (Methylphenidate) in rabbits at Metadate (Methylphenidate) up to 0. In rats given 20nbsp;times the human dose (1000nbsp;mcgkgday) during both gestation and lactation, maternal toxicity and growth retardation of the first generation offspring resulted in an increased rate of fetal death of the Metadate (Methylphenidate) generation offspring.

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